Only influenza vaccine approved for self- or caregiver-administration at home,
扩大流感保护的选择
FluMist has been approved in the US as the only self-administered influenza vaccine. FluMist, 无针鼻喷雾剂, was approved to be self-administered by adults up to 49 years of age or administered by a parent/caregiver to individuals 2-17 years of age.1
The approval by the US Food and Drug Administration (FDA) was based on a comprehensive submission, which included results from a usability study demonstrating that individuals over 18 years of age could self-administer or administer FluMist 2-49岁的合格个人.1
Ravi Jhaveri, MD, Division Head, Infectious Disease; Virginia H. 罗杰斯传染病学教授, 儿科教授(传染病), 西北大学医学院, Chicago, US, 他说:“这是第一次, families and caregivers will be able to protect themselves against influenza with a needle-free, 自行管理的疫苗, 远离自己家的便利. Each year, 流感对人们造成重大负担, society and health systems; additional tools to increase access to vaccinations, 同时也减少了差距, are critical."
Iskra Reic, 执行副总裁, 疫苗和免疫疗法, AstraZeneca, 说:“批准。 FluMist for self-administration is an important step forward in making vaccines more accessible to fight the high annual burden of influenza. 20多年来， FluMist has been the only nasal spray flu vaccine licensed in the US and now it is also the only vaccine to help individuals, families and communities access an influenza vaccine conveniently through self- and caregiver administration outside of traditional healthcare settings.”
Seasonal influenza causes up to 1 billion infections each year and may result in severe outcomes for about 3-5 million patients including hospitalisations, 并发症和死亡.2 Influenza has been shown to impact school attendance and employment with 47% of days of school and 1-2 days of work missed annually.3,4 Vaccination rates for influenza have declined in adults in the US since the 2020–21 season by 3.3%.5 在一项美国调查中, a common reason for adults not to receive a vaccination included failure to attend regular well-care visits, while having access to at-home vaccination options were shown to potentially increase influenza vaccination uptake.6
一旦可用, individuals 18 and older will be able to have FluMist delivered directly to their homes via FluMist Home. FluMist Home will utilise an online pharmacy where eligible individuals complete a questionnaire that is reviewed by a pharmacist prior to receiving their vaccine for shipment. FluMist will continue to be available in offices and pharmacies for administration by healthcare professionals. 更多信息请访问 www.FluMist.com.
Notes
Influenza
On average, 每个季节大约有8%的美国人患流感, 幅度在3%到11%之间, 视季节而定.7 在2022-2023年流感季节期间, 估计有3100万人因流感而患病, 有1400万人因为流感去医疗机构就诊, with 360,000年住院治疗上, and 21,000 deaths.8
About FluMist 流感减毒活疫苗
FluMist 是一种流感减毒活疫苗(LAIV), which is administered as a nasal spray for the prevention of influenza. FluMist is an Advisory Committee on Immunization Practices (ACIP) and American Academy of Pediatrics (AAP) recommended influenza vaccine option. FluMist was originally approved in the US in 2003 and since then almost 200 million doses have been distributed around the world.1
流感药物自我用药的人为因素可用性研究
在fda要求的人为因素/可用性研究中, AstraZeneca evaluated if individuals 18 through 49 years of age could appropriately administer FluMis当被告知使用说明时. The results showed that 100% of intended users administered a full dose. In addition, data show that efficacy, immunogenicity and adverse events with self-administration of FluMist 与hcp疫苗接种相似吗.1,9 The FluMist label has been updated to provide additional instructions for ordering and administration for eligible self and caregiver use. Children 2-8 years of age with an uncertain vaccination history may not be eligible for caregiver use and should consult their healthcare provider for further information.1
AstraZeneca
澳门在线赌城娱乐(LSE/STO/Nasdaq: AZN)是一家全球性制药公司, 以科学为主导的澳门第一赌城在线娱乐公司，专注于发现, development, 以及肿瘤学处方药的商业化, 罕见疾病, 和澳门第一赌城在线娱乐, 包括心血管, Renal & 新陈代谢和呼吸 & Immunology. 总部设在剑桥, UK, AstraZeneca’s innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit verbanecphotography.com 并在社交媒体上关注公司 @AstraZeneca.
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References
1. 处方信息. March 2024.
2. 世界卫生组织. (季节性流感. URL: http://www.who.int/news-room/fact-sheets/detail/influenza(seasonal)#:~:text=There%20are%20around%20a%20billion,感染% 20 % 20 % 20发展中% 20个国家.
3. McLean, HQ, Peterson, SH, King, JP, Meece, JK和Belongia, EA. School absenteeism among school-aged children with medically attended acute viral respiratory illness during three influenza seasons, 2012-2013至2014-2015年. 流感及呼吸病毒. 2017; 11, 220–229. http://doi.org/10.1111/irv.12440
4. 布兰切特·祖莫芬，MH.弗林普特，J. & Hansen, S.A. Impact of Influenza and Influenza-Like Illness on Work Productivity Outcomes: A Systematic Literature Review. 中国医药科学，2009,33(4):344 - 344。. http://doi.org/10.1007/s40273-022-01224-9
5. 疾病控制和预防中心. 流感疫苗接种覆盖率，美国，2022-23年流感季节. URL: http://www.cdc.gov/flu/fluvaxview/coverage-2223estimates.htm
6. Anderson EL. Recommended solutions to the barriers to immunization in children and adults. Mo Med. 2014 Jul-Aug; 111 (4): 344 - 8. PMID: 25211867; PMCID: PMC6179470.
7. 疾病控制和预防中心. 流感的重要资讯(流感). URL: http://www.cdc.gov/flu/about/keyfacts.htm
8. 疾病控制和预防中心. 初步估计的流感病例, 医疗访问, 住院治疗, 和美国死亡人数- 2022-2023年流感季节. URL: http://www.cdc.gov/flu/about/burden/2022-2023.htm
9. Burgess, T.H., Murray, C.K., Bavaro, M.F.兰德勒姆，M.L.O'bryan, T., Rosas, J.G.卡玛拉塔，南卡罗来纳州.M., Martin, N.J., Ewing, D.F.拉维普拉卡什，K., Mor, D., Zell, E.R., Wilkins, K.J., & Millar, E.V. (2015). Self-administration of intranasal influenza vaccine: Immunogenicity and volunteer acceptance. 疫苗，33 32,3894-9 . DOI:10.1016/j.vaccine.2015.06.061
Adrian Kemp
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